Markedly decreased CSF hypocretin-1 levels could be a significant marker for identifying subgroups of narcolepsy patients without cataplexy. In patients who have narcolepsy without cataplexy, short mean REM latency, younger age at onset, and HLA-DR2 are associated with CSF hypocretin-1 deficiency. Early clinical studies indicated that sodium oxybate had the potential to reduce cataplexy attacks associated with narcolepsy 22 and improve sleep quality 23. Some narcoleptic patients without cataplexy have low CSF hypocretin-1 levels. People with narcolepsy may unwillingly fall asleep even in the middle of an activity like driving. According to the National Institutes of Health, narcolepsy is a chronic neurological disorder that affects the brain’s ability to control sleep-wake cycles. HLA-DR2 was positive in all of the patients with low CSF hypocretin-1, whereas only 33.3% of patients with normal CSF hypocretin-1 were DR2 positive. Research Study for Adults 18 to 64 Years Old with Type 1 Narcolepsy with Cataplexy. The mean rapid eye movement (REM) latency was significantly shorter and the age at onset was significantly earlier in the low CSF hypocretin-1 group compared with the normal CSF hypocretin-1 group. INERVENTIONS: Patients underwent lumbar puncture for CSF sampling.įive patients showed a markedly decreased CSF hypocretin-1 level, whereas the remaining 12 patients showed almost normal levels. Narcolepsy is a chronic disorder that is primarily characterized by excessive daytime sleepiness and, in the majority of individuals, cataplexy (a sudden loss of muscle tone during wakefulness. Seventeen patients (5 male, 12 female) who fulfilled the diagnostic criteria of narcolepsy without cataplexy according to the International Classification of Sleep Disorders. Type 2 Narcolepsy: This form was previously referred to as narcolepsy without cataplexy. They may also have low levels of the neurotransmitter hypocretin in their brain. People who have this type experience excessive daytime sleepiness along with cataplexy. University-based sleep laboratories and a sleep disorders center. Type 1 Narcolepsy: This form was previously referred to as narcolepsy with cataplexy. Our aim was to examine whether clinical characteristics vary with CSF hypocretin-1 levels among narcoleptic patients without cataplexy.Ĭlinical features, variables on the multiple sleep latency test, and results of HLA typing were correlated with CSF hypocretin-1 levels. Cerebrospinal fluid (CSF) hypocretin-1 levels and their relationship with the clinical characteristics of narcolepsy without cataplexy have not been well elucidated. The American Academy of Sleep Medicine Foundation (AASM Foundation) recently partnered with Wake Up Narcolepsy to award a Strategic Research Grant on topics.
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